Search for PCQuorum database
I can help you find agent interactions. If you do not want this assistance or want to cancel at any time, pressESC key
Search by organism
Select an antimicrobial interactions network from the database lookup list
For example select P. aeruginosa - regulation
Search by antimicrobial interaction
Now we try to perform more complex searches to access more refined information.
For example select P. aeruginosa - regulation
Search by antimicrobial agent
Select one antimicrobial agent in order to view all antimicrobial interactions
For example select AlgR
Search by antimicrobial agent
Here you can select one antimicrobial agent in order to view all interactions experimented for one compound related with P. aeruginosa - regulatio.
For example select 5-Fluorouracil
Select all nodes related to two sources and targets
Below we will find a path between two antimicrobials agents for this it's needed pass through with others in order to find a possible relationship
For example select Baicalein
Select another antimicrobials agent
Now select Morin
You are ready to trigger the search!
Click in the search button order to view the specified antimicrobial interaction network
Reset all options in order to view another example
Please, click in reset button to continue with tutorial.
One last example
Below we will look for all nodes that are related by antagonism.
Please select Stimulation option
Changing the node size
Here you can change all node size. Please, try it.
Searching one node in current network
You can change the size of one specific node in order to find it.
For example write lasB
Optimising search
You can use this option in order to search only the path between the two nodes (without there directly related nodes)
All nodes whit same size
You can use this option in order to fix all node size in the network
You may explore the requested network
Following our example, you can see the network representing all interactions related to
P. aeruginosa - regulation network. You may explore the network by clicking and dragging with the mouse. You can also change the
zoom level
with the
mouse wheel.(Only after clicking in network!)
You may explore the requested network
This is the AlgR interaction network.
You may explore the requested network
Wow! This network is too large.
Maybe you can not see the node that you were looking for...
ok let's fix it
You may explore the requested network
Here you can see the compound 5-Fluorouracil in relation to the P. aeruginosa - regulation network.
When the tutorial ends you can click in one node or one edge in order to obtain more information about it.
You may explore the requested network
Here you can see a possible (undirected)path between two different antimicrobials agents and nodes that are directly related.
if there is no path only it is showed part of the path that has been found.
How to understand the network
Now you can see all lasB nodes with a different size.
Maybe you're wondering, what colors of each node and its size this shape corresponds?
Our legend
Here you can a common legend for all networks.
The colors of each node (as well as its size) correspond to the number of relationships that it has.
Each type of node has a specific shape such as a circle, a square, etc. You must be pay attention of
this legend, because it can be changed when the database grows.
Search by regulation or anti-QS
Enter one or more interaction network related to Pseudomonas Aureginosa . The web will attempt to do auto-completion on the string you have entered based on the contents of the database.
If you select one of the auto-complete options, then when you submit the form you will be taken all antimicrobial interactions in database related to the network selected.
Search by antimicrobial agent
Enter a antimicrobial agent. The web will attempt to do auto-completion on the string you have entered based on the contents of the database.
If you select one of the auto-complete options, then when you submit the form you will be taken the antimicrobial agent selected and all agents that interact with this.
Search by antimicrobial interaction
if you select a source and a target,
then when you submit the form you will be taken a possible way of investigation between antimicrobial A and antimicrobial B through different nodes as well as direct nodes on both agents.
Search by interaction type
Enter one antimicrobial interaction. The web will attempt to do auto-completion on the string you have entered based on the contents of the database.
If you select one of the auto-complete options, then when you submit the form you will be taken all antimicrobial interactions in database related of type selected.
Combinate all options for more advanced filters
You can use only one option of form or you can combine all the different options for find more specific data, for example a specific interaction (Ex. Stimulation/Activation) related to an organism (Ex. Pseudomonas Aureginosa)
More help in guideline tour
If you need further assistances it is recommended view the guideline tour
Node Size
Edge Size
These data are for the whole network, once you select a sub-network, statistics will be search-dependent.
Calculating data...
This heat map represents the strength of the antimicrobial combinations in the database. Click in one cell to obtain the corresponding network
Specifically, it details for each antimicrobial agent in the database the number of studies that reporting a given combinatory effect.
Antimicrobial Agents | Activation | Antagonism | Codification | Deactivation | Downregulation | Dual regulation | Inhibition | Interaction | Stabilization | Stimulation | Unknown effect | Upregulation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Too big to show, please select one node |
Data for the selected network
Data for the selected network
This antimicrobial combination will be permanently deleted and cannot be recovered. Are you sure?